Comparison of the Effect of Gabapentin and Evening Primrose Oil on Peripheral Neuropathy Pain in Patients with Type 2 Diabetes
نویسندگان
چکیده مقاله:
Background and Objective: Neuropathic pain is one of the common, important, and irritating complications in diabetes. Despite the importance of this pain, there is still no effective treatment for that. The aim of this study was to determine the effect of evening primrose oil and gabapentin on neuropathic pain in patients with type 2 diabetes. Materials and Methods: This triple-blind clinical trial was performed on 70 patients with diabetic neuropathy who obtained score 2 from the Michigan Questionnaire and referred to the Department of Endocrinology at Khayyam clinic affiliated to Hakim Hospital in Neyshabour from December 2017 to May 2018. The participants were divided into two groups of 35 people. The intervention group was treated with a capsule of evening primrose oil orally (1000 mg) twice daily for three months and gabapentin (300 mg) daily. On the other hand, the control group was treated with gabapentin (300 mg) and placebo. The neuropathy pain severity was measured before and after the end of three-month intervention using Michigan and McGill Pain Questionnaires. Data analysis was performed in SPSS software (version 21) through Fisher's exact test, ANCOVA, multilevel logistic regression, Mann Whitney U test, Kolmogorov-Smirnov test, and the Chi-square tests. P-value less than 0.05 was considered statistically significant. Results: According to the results obtained from the McGill questionnaire, the mean scores of neuropathy before the intervention were obtained at 10.12±0.57 and 9.85±0.65 in the intervention and control groups, respectively. However, the mean scores of neuropathy after the intervention were estimated at 6.18±0.48 and 8.31±0.60 in the intervention and control groups, respectively, which was statistically significant (P<0.02). Conclusion: Evening primrose oil is effective in reducing neuropathic pain in type 2 diabetic patients. Therefore, this can be a supplementary treatment for reducing pain associated with diabetic neuropathy.
منابع مشابه
The Risk Factors in Serum of Peripheral Neuropathy Diabetic and Type 2 Diabetes Patients
Aims: The study's purpose was to evaluate the serious risk factor for the neuropathy disease in patients with diabetes Material & Methods: This research was done on 120 subjects classified into 40 with DPN T2DM and 40 with T2DM and 40 healthy considered as a control. As the conditions of the Iraqi Ministry of Health to evaluate the thesis clinically, that the number of samples examined should ...
متن کاملthe effect of aqueous extract of garlic on formalin-induced pain in male rats
چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...
15 صفحه اولthe past hospitalization and its association with suicide attempts and ideation in patients with mdd and comparison with bmd (depressed type) group
چکیده ندارد.
the effect of explicit teaching of metacognitive vocabulary learning strategies on recall and retention of idioms
چکیده ندارد.
15 صفحه اولcomparative study of pain relieving effect of dry cotton pellet and eugenol cotton pellet in the reduction of pain in emergoney pulpotomy
چکیده ندارد.
15 صفحه اولthe washback effect of discretepoint vs. integrative tests on the retention of content in knowledge tests
در این پایان نامه تاثیر دو نوع تست جزیی نگر و کلی نگر بر به یادسپاری محتوا ارزیابی شده که نتایج نشان دهندهکارایی تستهای کلی نگر بیشتر از سایر آزمونها است
15 صفحه اولمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 26 شماره 1
صفحات 5- 11
تاریخ انتشار 2019-06
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
کلمات کلیدی برای این مقاله ارائه نشده است
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023